An isocaloric high fat diet affects peripheral circadian clock and diurnal rhythms of inflammatory genes in humans
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES(2014)
Abstract
Introduction: The clock gene machinery coordinates numerous metabolic processes to adapt physiological responses to light-dark and feeding regimens. However, in humans it is unknown whether clock genes participate in nutrient-induced metabolic and inflammatory responses. Herein, we hypothesized that the switching from high carbohydrate – low fat diet to a low carbohydrate – high fat (LC/HFD) isocaloric diet affects the molecular circadian clock and potentially alters diurnal rhythms in fat metabolism and inflammation in human monocytes.
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Key words
peripheral circadian clock,isocaloric high fat diet,diurnal rhythms,inflammatory genes
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