Development of a Practical, Biocatalytic Reduction for the Manufacture of ( S )-Licarbazepine Using an Evolved Ketoreductase
Organic Process Research & Development(2014)
摘要
This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbazepine).
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关键词
biocatalytic reduction
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