Development of a Practical, Biocatalytic Reduction for the Manufacture of ( S )-Licarbazepine Using an Evolved Ketoreductase

Brian Wong, Zhang Wei,Derek Smith, S M Palanivel,Scott Novick,Karthik Narayanaswamy, Raquel Keledjian,Gjalt W Huisman,Anupam Gohel, Ann Shu Chan,Steven J Collier,Joly Sukumaran,Naga K Modukuru,David A Entwistle,Wan Lin Yeo

Organic Process Research & Development（2014）

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摘要

This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbazepine).

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biocatalytic reduction

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