Crystallization of a Cephalosporin and an ERR-1: Assembly of an Inexpensive Crystallization Platform

Finding a stable crystalline form of a small molecule API can be a daunting task given short timelines and the importance of having a crystal form in the development of the molecule. Crystalline forms of small molecules are sought for various reasons, such as purity, chemical, and/or physical stability. In this report, we will highlight the design and process that was utilized to develop an inexpensive and simple screening platform. Our goal was to utilize existing equipment and to develop a straightforward workflow that would enable us to quickly define a set of scalable crystallization conditions and prepare a sample of the target cephalosporin and ERR-1 for preclinical testing.