Leptin and Il-17 mediated responses in vaccination against Helicobacter pylori

Infection with Helicobacter pylori causes chronic inflammation and damage to the gastric epithelium. This leads to chronic gastritis, and in a proportion of patients, ulcer, or gastric cancer. Candidate H. pylori vaccines tested in volunteers to date have proved poorly immunogenic and/or to induce adverse reactions. Indeed there is some evidence that “post immunisation gastritis” occurs because the tightly controlled inflammatory response in the gastric mucosa is unbalanced [1].