A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections

Hao Li,Xiaoguang Lei,Baihui Huang,Joshua D. Rizak,Lichuan Yang,Shangchuan Yang,Jing Wu,Longbao Lü,Jianhong Wang,Ting Yan, Hongwei Li,Zhengbo Wang,Yingzhou Hu,Weidong Le,Xingli Deng,Jiali Li,Lin Xu,Baorong Zhang,Xintian Hu

Journal of Neuroscience Methods（2015）

Cited 16|Views48

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Abstract

•Through this new method, the researcher can quantitatively develop PD monkey model of specific PD stage in a specified time period.•The monkeys have stable PD symptoms, low individual variation and good general conditions.•This new PD monkey model also has typical pathological changes of Parkinsonism.

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Key words

Parkinson's disease,Non-human primate animal model,Intracerebroventricular administration,MPP+,Dopaminergic cell loss

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