Evaluación longitudinal con FP-CIT en pacientes con parkinsonismo

Objective: To assess a group of patients with parkinsonism using serial studies with FP-CIT, basically the initial false negative results. Methods: Restrospective study of 92 patients (55 men and 37 women) who had undergone 2 different FP-CIT studies because of discrepancies between study results and clinical progression. The mean elapsed time between the studies was 26 months (SD: 6). We performed a semi-quantitative study using the patient's clinical history and the available literature to analyse discrepant cases with a normal initial study and subsequent pathological findings. Results: A total of 184 studies were completed for 92 patients; 11 of those 92 showed discrepancies between initial and subsequent studies. Among the 11 discrepant cases, 7 showed a normal initial study and pathological findings at a later date. Analysis of the predominant clinical features that might explain this behaviour revealed that 4 of these 7 subjects presented tremor-dominant parkinsonism. Regarding the rest, 1 presented early stage parkinsonism and was treated with antidopaminergic agents; 1 was classified as probable multisystem atrophy type C, and the third showed clinical signs of atypical parkinsonism without any causes of those signs being identified. Conclusions: Serial FP-CIT studies are unnecessary in the large majority of cases, but they may be justifiable in certain clinical situations. (C) 2013 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.