High-Resolution Scanning Tunneling Microscopy Imaging of Biotin–Avidin–G4-DNA Molecules
Journal of Physical Chemistry C(2013)
Abstract
The morphological structure of G4-DNA wires having four parallel strands, made by a novel synthesis method, was revealed by high-resolution scanning tunneling microscopy (STM). This imaging technique is a unique alternative to obtain information on the molecular structure of these wires in the absence of X-ray and NMR data. Imaging reveals a periodic structure seen as repeating “bulbs” along the molecule. The bulbs correspond to the helical structure of the molecules. The STM imaging shows a molecular chain structure. This structure exhibits an average periodicity of 3.5 nm and an average molecular apparent height of 1.4 nm.
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Key words
biotin–avidin–g4-dna,biotin–avidin–g4-dna,molecules,high-resolution
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