Enhanced allogeneic cellular responses to mismatched HLA-B antigens results in more efficient killing of HIV infected cells.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES(2016)
摘要
Epidemiologic studies have demonstrated that HIV-1 discordant couples who share HLA-B alleles were more likely to transmit HIV-1. These data lead us to hypothesize that individuals who match at both HLA-B alleles should have a reduced allogeneic response than those who are not matched. We observed diminished killing of CD4(+) target cells only when HLA-B alleles were matched. We propose that for cell-associated HIV-1 transmission, the ability of the recipient to eliminate infected cells from a donor partner may be enhanced when HLA-B alleles are different between partners. These findings suggest a novel mechanism for protection against HIV infection.
更多查看译文
关键词
allogeneic responses,T cells,cytotoxic T-cells,mixed lymphocyte reaction,HLA-B,HIV-1 transmission
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要