081 — (TRO0111) Role of alpha1-adrenoceptors in one injection-induced behavioral sensitization to morphine

Rationale: Behavioral sensitization (an animal model of drug addiction-related neuroplasticity) can occur after a single injection of a drug of abuse, and this phenomenon can be influenced by several factors. The physiological mechanisms implicated in the development of opiate dependence consist of maladaptive changes that include processes of homologous regulation, affecting the endogenous opioid system, and heterologous regulation, affecting other neurotransmitter systems.