059 — (PRO0041) Adolescent mice are more vulnerable than adults to the rewarding effects of ecstasy (MDMA)

Rationale: 3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is an illicit recreational psychostimulant consumed by many teenagers and adults. In parallel, it has been demonstrated that drugs with abuse potential induce conditioned place preference (CPP), an animal model to evaluate the rewarding properties of drugs, in rodents. Therefore, the aim of the present study was to investigate, in adolescent and adult mice, the effects of MDMA on the CPP procedure.