035 Switching patients from clopidogrel to prasugrel at the early phase of an acute coronary syndrome: impact of prasugrel reloading

with minor effect in *2/*2 carriers. After 900mg LD, the effect of the CYP2C19*2 variant on platelet inhibition was fully compensated in wt/*2 carriers but not in *2/*2 carriers (–83.6±25.8% in wt/wt vs. –77.2±26.9% in wt/ *2 vs. –29.5±26.8% in *2/*2; overall p-value=0.0003, p=0.20 for wt/wt versus wt/*2, p<0.001 for wt/*2 versus *2/*2). A similar pattern was observed for the active metabolite AUC0-6 and there was a significant correlation between PK and PD responses irrespective of the LD.