Minimum Information about a Biosynthetic Gene cluster

Marnix H Medema,Renzo Kottmann,Pelin Yilmaz,Matthew Cummings,John B Biggins,Kai Blin,Irene de Bruijn,Yit Heng Chooi,Jan Claesen,R Cameron Coates,Pablo Cruz-Morales,Srikanth Duddela, Stephanie Düsterhus,Daniel J Edwards,David P Fewer,Neha Garg, Christoph Geiger,Juan Pablo Gomez-Escribano,Anja Greule,Michalis Hadjithomas,Anthony S Haines,Eric J N Helfrich,Matthew L Hillwig,Keishi Ishida,Adam C Jones, Carla S Jones,Katrin Jungmann,Carsten Kegler,Hyun Uk Kim,Peter Kötter,Daniel Krug,Joleen Masschelein,Alexey V Melnik,Simone M Mantovani,Emily A Monroe, Marcus Moore,Nathan Moss,Hans-Wilhelm Nützmann,Guohui Pan,Amrita Pati,Daniel Petras,F Jerry Reen,Federico Rosconi,Zhe Rui,Zhenhua Tian,Nicholas J Tobias,Yuta Tsunematsu,Philipp Wiemann,Elizabeth Wyckoff,Xiaohui Yan,Grace Yim,Fengan Yu,Yunchang Xie,Bertrand Aigle,Alexander K Apel, Carl J Balibar,Emily P Balskus,Francisco Barona-Gómez,Andreas Bechthold,Helge B Bode,Rainer Borriss,Sean F Brady,Axel A Brakhage,Patrick Caffrey,Yi-Qiang Cheng,Jon Clardy,Russell J Cox,René De Mot,Stefano Donadio,Mohamed S Donia,Wilfred A van der Donk,Pieter C Dorrestein,Sean Doyle,Arnold J M Driessen,Monika Ehling-Schulz,Karl-Dieter Entian,Michael A Fischbach,Lena Gerwick,William H Gerwick,Harald Gross,Bertolt Gust,Christian Hertweck,Monica Höfte,Susan E Jensen,Jianhua Ju,Leonard Katz,Leonard Kaysser,Jonathan L Klassen,Nancy P Keller,Jan Kormanec,Oscar P Kuipers,Tomohisa Kuzuyama,Nikos C Kyrpides,Hyung-Jin Kwon,Sylvie Lautru,Rob Lavigne,Chia Y Lee,Bai Linquan,Xinyu Liu,Wen Liu,Andriy Luzhetskyy,Taifo Mahmud,Yvonne Mast,Carmen Méndez,Mikko Metsä-Ketelä,Jason Micklefield,Douglas A Mitchell,Bradley S Moore,Leonilde M Moreira,Rolf Müller,Brett A Neilan,Markus Nett,Jens Nielsen,Fergal O'Gara,Hideaki Oikawa,Anne Osbourn, Marcia S Osburne,Bohdan Ostash, Shelley M Payne,Jean-Luc Pernodet,Miroslav Petricek,Jörn Piel, Olivier Ploux,Jos M Raaijmakers,José A Salas,Esther K Schmitt,Barry Scott,Ryan F Seipke,Ben Shen,David H Sherman,Kaarina Sivonen,Michael J Smanski,Margherita Sosio,Evi Stegmann,Roderich D Süssmuth,Kapil Tahlan,Christopher M Thomas,Yi Tang,Andrew W Truman,Muriel Viaud,Jonathan D Walton,Christopher T Walsh,Tilmann Weber,Gilles P van Wezel,Barrie Wilkinson,Joanne M Willey,Wolfgang Wohlleben,Gerard D Wright,Nadine Ziemert,Changsheng Zhang,Sergey B Zotchev,Rainer Breitling,Eriko Takano,Frank Oliver Glöckner

NATURE CHEMICAL BIOLOGY（2015）

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摘要

wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

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关键词

database,resource,synthetic biology,biosynthesis,scale

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