The effect of menopause and gender on lipids and HDL cholesterol subfractions in apparently healthy pre- and postmenopausal women and men

analysis revealed a marked decrease of apolipoprotein B100 and an increase of apolipoprotein M in plasma of H2 group. Finally H2 treatment resulted in significant reductions in levels of several inflammatory and oxidative stress indicators in whole plasma and HDL particles. Conclusions: Hydrogen activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL anti-atherosclerotic functions, and has beneficial lipid-lowering effects. The present finding may highlight the potential role of hydrogen in the regression of hypercholesterolemia and atherosclerosis.