Biocatalytic Transformations of Steroids: Focus on Hydrolase-Catalyzed Reactions
Current Organic Chemistry(2011)
摘要
Steroids comprise several classes of structurally related molecules with multiple bioactivities. Due to their complexity, the selective modification of these polycyclic compounds is challenging. This review outlines recent developments in the use of biocatalysts for the transformation of steroids, specifically focusing on the synthetic exploitation of hydrolases. Accordingly, several regio- and stereoselective acylations and deacylations mediated by lipases and proteases are discussed en route to preparation of new derivatives with useful application in pharmaceutical and food chemistry.
更多查看译文
关键词
Acylations,hydrolases,lipases,polyhydroxylated compounds,proteases,selectivity,steroids
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要