Synthesis of hydrogenated 2,7-dimethylpyrrolo[3,4- b ]indoles – analogs of dimebon

schemes have been proposed for the synthesis of novel 4-substituted 2,7-dimethyl-3,4-dihydro-1H- and previously unknown 2,7-dimethyl-cis-1,2,3,3a,4,8 b -hexahydropyrrolo[3,4- b ]indoles. In the case of the Dimebon structural analog 2,7-dimethyl-4-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrrolo-[3,4- b ]indole a broad spectrum of pharmacological activity was found in the hydrogenated pyrroloindoles suitable for the development of medicines via the “magic bullet” concept. A strong dependence of the antagonist relationship of the synthesized compounds towards histamine H 1 and serotonin 5-HT 6 receptors with the nature of the substituent in the 4 position and the degree of hydrogenation of the pyrrolo[3,4- b ]indoles was demonstrated.