Expression and function of methylthioadenosine phosphorylase (MTAP) in activated hepatic stellate

Regain methionine is essential for cellular metabolism and methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme in the methionine and adenine salvage pathway, catalyzes the phosphorylation of 5'-deoxy-5'-(methylthio)adenosine (MTA), which is a by-product of polyamine synthesis. The polyamine metabolic pathway has been implicated in the pathogenesis of chronic liver disease, and previous studies have shown that pharmacological doses of MTA (500µM and higher) exhibited anti-fibrotic effects in murine models of hepatic injury.