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Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

X Cheng, M Boxtermann,B Höchst,JH Bockmann, R Bester,B Holzmann,P Knolle,N Hüser,D Hartmann,K Esser, U Protzer

Zeitschrift Fur Gastroenterologie（2015）

Cited 0|Views17
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Abstract
Hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Within days post infection, innate immunity is activated by HCV reflected by an induction of IFN-stimulated genes (ISGs). The precise cell type and cellular pathogen pattern recognition receptors (PRRs) involved in innate immune sensing of HCV, however, still remain unknown.
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Key words
hcv,immune response,endothelial cells,kupffer cells,liver sinusoidal
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