HLA B*27 subtype specificity determines the targeting of HLA B*27 restricted HCV specific CD8+ T cell epitopes
Zeitschrift Fur Gastroenterologie(2013)
Abstract
The HLA class I allele B*27 is associated with spontaneous viral clearance in Hepatitis C virus (HCV) genotype 1 infection. This protective effect of HLA-B*27 is linked to an immunodominant epitope as well as a subdominant epitope, both located in the HCV polymerase NS5B. Viral escape mutations occur consistently in these two epitopes in chronically infected patients and can abolish recognition of these epitopes by CD8+ T cells.
MoreTranslated text
Key words
Epitope,Cytotoxic T cell,HLA-B,Virology,Biology
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined