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Human intestinal and systemic adaptation of iron metabolism and transport to hypoxia in healthy mountaineers after rapid ascent to 4559m

Heiko Fruehauf,Oliver Goetze,J Schmitt,Kerstin Spliethoff,Kacper A Wojtal,Marco Maggiorini,Thomas A Lutz,Andreas Geier

Zeitschrift Fur Gastroenterologie（2011）

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Abstract
Background & aims: Human iron metabolism is closely regulated by erythropoesis, oxygen homeostasis and intestinal iron absorption. The aim of this study was to characterize for the first time the adaptation of iron metabolism and transport to hypoxia under high altitude conditions in man at the levels of (i) intestinal iron uptake (ii) changes in systemic iron homeostasis and hemoglobin in one comprehensive overview.
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Key words
iron metabolism,hypoxia,healthy mountaineers
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