The disease susceptibility risk mediated by gene variants in PHOX2B, NCF4, FAM92B, and in the intergenic region on chromosome 10q21.1 differs between North American and European patients with Crohn's disease

Background and Aims: Very recently, a North American genome-wide association study identified three novel gene variants in PHOX2B, NCF4, and FAM92B as well as one SNP (rs224136) in the intergenic region on chromosome 10q21.1 to be associated with Crohn's disease (CD) (Nat Genet 2007;39:596–604.). However, their role in European patients with inflammatory bowel disease is unknown. Therefore, we aimed to replicate these novel CD susceptibility variants in a large European cohort with inflammatory bowel disease and analyzed potential gene-gene interactions with variants in the CARD15, IL23R, and ATG16L1 genes.