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Visceral hyposensitivity induced by congenitally elevated gut permeability turns to hypersensitivity after stress in CA-MLCK mice

O Inczefi,H Eutamene,M Leveque,C Bétoulières,R Róka,A Rosztóczy,T Wittmann,J Turner,V Theodorou,L Ferrier

Zeitschrift Fur Gastroenterologie（2014）

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Abstract
Background: Elevated gut permeability is linked to visceral hypersensitivity in patients with IBS. Using transgenic mice that express constitutively-active myosin light chain kinase (CA-MLCK) specifically within the intestinal epithelium in this way having gut hyperpermeability, we aimed to evaluate the pattern of visceral sensitivity and to determine putative mechanisms under basal and stress conditions.
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Key words
visceral hyposensitivity,gut permeability,hypersensitivity,mice,ca-mlck
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