Clinical And Immunologic Effects Of Maraviroc In Progressive Multifocal Leukoencephalopathy

Ananja Middel,Joop E. Arends,Steven F. L. Van Lelyveld,Sigrid Otto,Rob Schuurman, Catharina J. M. Frijns,Kiki Tesselaar,Andy I. M. Hoepelman

NEUROLOGY（2015）

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摘要

Progressive multifocal leukoencephalopathy (PML) is a rare but generally fatal disease due to JC virus (JCV) reactivation, mainly occurring in immunosuppressed patients.(1) Therapeutic options are limited to blocking glial cell infection by mirtazapine or restoring cell-mediated immunity to acquire viral control.(2)

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