Hereditary neuropathy with liability to pressure palsies (HNPP) and leprosy neuropathy: a comparative nerve conduction study. (P3.182)

Objective.Compare the neurophysiologic patterns of leprosy and HNPP, for early diagnosis and appropriate intervention.Background.Leprosy and HNPP are part of the differential diagnosis of multiple mononeuropathy with focal slowing, preferably at sites of compression.Often the differential diagnosis between pure neural leprosy and HNPP without family history is difficult.Methods.We reviewed electrophysiological features of 33 HNPP patients and 75 leprosy patients.Results.The most prevalent neurophysiologic pattern was asymmetric sensorimotor neuropathy with focal slowing:44 leprosy patients (58.7[percnt]) and 31 HNPP patients (94.0[percnt]). Among the leprosy patients, 16 (21.3[percnt]) had asymmetric axonal sensorimotor neuropathy, 9 (12.0[percnt]) asymmetric sensorimotor neuropathy predominantly sensory, 5 (6,7[percnt]) asymmetric sensory neuropathy and 1 (1.3[percnt]) mononeuropathy.None showed symmetric polyneuropathy. Among the HNPP patients, 1 had mononeuropathy and 1 unilateral brachial plexopathy associated with focal slowing.Variables of nerve conduction studies with the most significant difference (p Disclosure: Dr. Oliveira has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Onofre has nothing to disclose. Dr. Marques has nothing to disclose. Dr. Marques has nothing to disclose.