Gadd45b Mediates Electroconvulsive Shock Induced Proliferation of Hippocampal Neural Stem Cells

Heechul Jun,Syed Mohammed Qasim Hussaini,Chang Hoon Cho,John Welby,Mihyeon Jang

Brain Stimulation（2015）

引用 15|浏览27

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摘要

•Electroconvulsive shock (ECS) induces adult neurogenesis in the mouse dentate gyrus.•ECS promotes proliferation of quiescent radial glial-like (RGLs) neural stem cells.•ECS promotes proliferation of amplifying non-RGL neural precursors.•Gadd45b does not affect basal proliferation level of RGLs and non-RGL precursors.•Gadd45b is essential for ECS-induced proliferation of both RGLs and non-RGLs.

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关键词

Electroconvulsive shock,Gadd45b,Adult neurogenesis,Neural stem cells,Hippocampus

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