Efficient radiolabeling of rutin with I and biodistribution study of radiolabeled rutin
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY(2016)
摘要
The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided I-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered I-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected I-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin.
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关键词
Rutin,Radiolabeling,125,I,SPECT/CT,Biodistribution
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