PW03-023 – Role of S100A4 in inflammatory disorders

Tight association of the pro-inflammatory events with the pathogenesis of a majority of serious human diseases (neoplasia, neurodegenetarions, cardiovascular and others) in addition to inflammatory and autoinflammatory diseases is firmly documented. S100A4 is a metastasis-promoting gene whose expression has been found implicated in chronic inflammation. Earlier we have shown an immense upregulation of S100A4 in affected tissues and plasma of patients suffering from rheumatoid arthritis, psoriasis, dermato/polymyositis 1 - 3, as well as in pro-inflammarory pathways in tumor metastasis 4,5. However, its role in inflammation remains unclear.