IL-18 serum concentration is continuously elevated in typical familial Mediterranean fever with M694I mutation and can distinguish atypical type
Modern rheumatology / the Japan Rheumatism Association(2015)
Abstract
Results IL-1b, IL-6, IL-8, TNF-a, and IFN-g were not increased in either type of FMF in the remission state and in controls, and IL-6 was elevated during attack periods among patients. Serum IL-18 levels were significantly higher in typical FMF patients with M694I MEFV mutation in remission than in controls at the same level as flared Kawasaki disease, which further increased during attack periods. In contrast, IL-18 levels in atypical FMF with P369S-R408Q mutation or in typical FMF without M694I mutation was not increased, in either disease states.
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Key words
Serum Concentration,Gene Analysis,Kawasaki Disease,Familial Mediterranean Fever,Cytokine Profile
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