MATRIX METALLOPROTEINASE-9 IS ASSOCIATED WITH THE SEVERITY AND MAJOR ADVERSE CARDIOVASCULAR EVENT IN PATIENTS WITH SYSTOLIC HEART FAILURE

Tetsuji Morishita,Hiroyasu Uzui,Kenichiro Arakawa,Naoki Amaya,Kenichi Kaseno,Kentaro Ishida,Takehiko Sato,Yoshitomo Fukuoka,Hiroyuki Ikeda,Etsuko Ikeda,Ako Fujii, Machiko Koike,Yusuke Sato,Kaori Hisazaki,Junya Yamaguchi,Jongdae Lee,Hiroshi Tada

Journal of the American College of Cardiology（2014）

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摘要

Matrix metalloproteinase (MMP) species are upregulated in the failing human heart and influenced ventricular remodeling. We assessed the hypothesis that disparity between MMP-9 and tissue inhibitors of MMP-1 (TIMP-1) reflects the clinical manifestation and are related to prognostic risk in patients

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