Treatment with anti-IL12/23 agents improves fetuin and oxidative stress in parallel with endothelial glycocalyx, coronary function and myocardial twisting in patients with psoriasis

I. Ikonomidis,M. Varoudi,E. Papadavid,I. Andreadou, K. Gravanis, K. Theodoropoulos,G. Pavlidis,H. Triantafyllidi,D. Rigopoulos,J. Lekakis

Journal of the American College of Cardiology（2014）

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摘要

Fetuin inhibits vascular calcification. The effects of biological agents on fetuin, oxidative stress, vascular and LV function in psoriasis is unclear. 101 patients(age:50±12yrs) with psoriasis (PS)were randomized to an anti-TNF-a(n=31),an anti-IL12/23 regimen (n=32)or cyclosporine(n=38).At

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psoriasis,oxidative stress,fetuin,endothelial glycocalyx

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