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Chordal Rupture Correlates with Elastic Fibril Fragmentation and Disorganization of the Posterior Leaflet in Myxomatous Mitral Valve Prolapse: Implications for Leaflet Stability and Disease Progression

Purushothaman K-Raman,Meerarani Purushothaman,David Adams,Federico Milla,Patrick A. Lento,William N. O'Connor,Samin Sharma,Valentin Fuster,Pedro Moreno

Journal of the American College of Cardiology（2012）

Cited 0|Views15
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Abstract
Mitral valve leaflet stability is maintained by extra-cellular matrix and valvular interstitial cells (VICs). In myxomatous mitral valve prolapse (MMVP), decreased type I collagen and increased type III collagen and proteoglycan deposition as a result of reduced lysyl oxidase (LOX) expression may
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