التعرض لتلوث الهواء يؤثر على عدد دوران كرات الدم البضاء فى الحالات اللصحية: دور تركيب حبيبات الغبارو الإجهاد التأكسدى والملوثات الغازية. مشروع الرابتس
Inhalation Toxicology(2014)
Abstract
Studies have linked air pollution exposure to cardiovascular health effects, but it is not clear which
components drive these effects. We examined the associations between air pollution exposure and
circulating white blood cell (WBC) counts in humans. To investigate independent contributions of
particulate matter (PM) characteristics, we exposed 31 healthy volunteers at five locations with high
contrast and reduced correlations amongst pollutant components: two traffic sites, an underground train
station, a farm and an urban background site. Each volunteer visited at least three sites and was
exposed for 5 h with intermittent exercise. Exposure measurements on-site included PM mass and
number concentration, oxidative potential (OP), elemental- and organic carbon, metals, O-3 and NO2.
Total and differential WBC counts were performed on blood collected before and 2 and 18 h postexposure
(PE). Changes in total WBC counts (2 and 18 h PE), number of neutrophils (2 h PE) and
monocytes (18 h PE) were positively associated with PM characteristics that were high at the
underground site. These time-dependent changes reflect an inflammatory response, but the characteristic driving this effect could not be isolated. Negative associations were observed for NO2
with lymphocytes and eosinophils. These associations were robust and did not change after adjustment
for a large suite of PM characteristics, suggesting an independent effect of NO2. We conclude that
short-term air pollution exposure at real-world locations can induce changes in WBC counts in healthy
subjects. Future studies should indicate if air pollution exposure-induced changes in blood cell counts
results in adverse cardiovascular effects in susceptible individuals.
MoreTranslated text
Key words
air pollution,particulate matter
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