Synthesis of Chlorin–(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development
SYNTHESIS-STUTTGART(2015)
摘要
A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated.
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关键词
porphyrins,cycloaddition,alkynes,azides,click chemistry,medicinal chemistry
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