Simultaneous monitoring of intratidal compliance and resistance in mechanically ventilated piglets: A feasibility study in two different study groups

•Intratidal resistance–volume profiles change in a characteristic way depending on PEEP, tidal volume and the underlying mechanical properties of the lung.•In healthy lungs, intratidal resistance–volume profiles decline linearly.•A curved intratidal resistance decline might indicate pathological changes in the underlying mechanical lung properties.•Intratidal resistance–volume profiles might help guiding a lung protective ventilation setting.