Comparative mapping of host–pathogen protein–protein interactions
Current Opinion in Microbiology(2015)
Abstract
•Pathogens usurp host pathways via host–pathogen protein–protein interactions (PPIs).•Systematic PPI analysis provides mechanistic understanding of pathogen biology.•Host and pathogen genetic diversity can be leveraged to identify functional PPIs.•Network models of host–pathogen PPIs require integration of orthogonal datasets.
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