Selection maintaining protein stability at equilibrium
Journal of Theoretical Biology(2017)
摘要
The common understanding of protein evolution has been that neutral mutations are fixed by random drift, and a proportion of neutral mutations depending on the strength of structural and functional constraints primarily determines evolutionary rate. Recently it was indicated that fitness costs due to misfolded proteins are a determinant of evolutionary rate and selection originating in protein stability is a driving force of protein evolution. Here we examine protein evolution under the selection maintaining protein stability.
更多查看译文
关键词
Neutral theory,Positive selection,Evolutionary rate,Structural constraints,Protein abundance
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要