The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression

Anais Belledant,Helene Hovington, Luciana Garcia,Patrick Caron,Herve Brisson,Lyne Villeneuve,David Simonyan,Bernard Tetu,Yves Fradet,Louis Lacombe,Chantal Guillemette,Eric Levesque

European Urology（2016）

引用 32|浏览14

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摘要

The androgen-inactivating UGT2B28 enzyme modifies circulating testosterone and dihydrotestosterone levels in prostate cancer and is associated with disease aggressiveness.

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关键词

UDP-glucuronosyltransferase,Prostate cancer prognosis,Disease aggressiveness,Steroid metabolism,Circulating hormone levels

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