Modulation of acute lung injury (ALI) by lipid emulsions - dependency of the chemerin 23 receptor (ChemR23)?

Acute lung injury (ALI) is a major cause of morbidity and mortality in intensive care units. Lipid emulsions (LE) used for parenteral nutrition might influence patient outcome due to provision of n-6 lipids as precursors of pro-inflammatory lipid mediators. In contrast, the n-3 fatty acids (FA) and their derived lipid mediators, including resolvins, were shown to reduce inflammatory responses. The chemerin receptor 23 (ChemR23) was identified to deliver the anti-inflammatory actions of chemerins as well as resolvin E1. In a model of ALI, we determined possible effects of emulsions providing n-6 or n-3 lipids and the role of the ChemR23.