Clinical patterns of hepatocellular carcinoma (HCC) in non alcoholic fatty liver disease (NAFLD): a multicenter case-control study

the AFP, the poorer the prognosis, but no good evidence in the literature exists on the minority of patients with HCC who do not secrete AFP. Our aim was to analyse this sub-group of patients from a cohort with advanced HCC treated with Sorafenib, and assess survival outcomes. Methods: Consecutive patients with a confirmed diagnosis of HCC as per AASLD criteria, treated with Sorafenib at Queen Elizabeth Hospital Birmingham UK, between April 2009 and March 2014 were included in the analysis. We took our local reference range of 400ng/ml (HR: 1.02, p = 0.89). The Kaplan–Meier curve presented shows the separation of survival curves for the 3 groups. Conclusions: There is very little published in the literature about the AFP non-secretor HCC sub-group. Our data shows that this sub-group has better prognosis compared to patients with AFP secretory HCC. We believe that this data is important for clinicians and patients for prognostication and decision making. P0340 CLINICAL PATTERNS OF HEPATOCELLULAR CARCINOMA (HCC) IN NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD): A MULTICENTER CASE–CONTROL STUDY F. Piscaglia, G. Svegliati Baroni, A. Barchetti, A. Pecorelli, S. Marinelli, C. Tiribelli, S. Bellentani, HCC-NAFLD Italian Study (full list exceeds available space) Bolondi L, Zoli M, Trevisani F, Malagotti D, Bugianesi E, Vanni E, Mezzabotta L, Cabibbo G, Petta S, Fracanzani A, Fargion S, Marra F, Fani B, Sacco R, Morisco F, Caporaso F, Guarino M, et al.. Dpt of Medical and Surgical Sciences, University of Bologna, Uni of Internal Medicine, University of Bologna, Bologna, Gastroenterology, University of Ancona, Ancona, Liver Research Center, Science Park – Basovizza Campus, Trieste, Italy E-mail: fabio.piscaglia@unibo.it