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Characterization of miR-99a(similar to)125b-2 polycistron in hematopoiesis and leukemogenesis

S. Emmrich,K. Henke,M. Rasche,D. Reinhardt,J. H. Klusmann

Klinische Padiatrie（2011）

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Abstract
Introduction: We previously linked high expression of human chromosome 21 (hsa21) encoded miR-125b-2 to the increased risk of children with trisomy 21 (Down Syndrome; DS) to develop acute megakaryoblastic leukemia (DS-AMKL). MiR-125b-2 resides in a tricistronic miRNA cluster harboring miR-99a/let-7c/miR-125b-2.
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mRNA modification
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