Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2015）
Abstract
Ribose modified 1-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbruggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
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Key words
Nucleosides,1-cyano pyrimidine nucleosides,HCV
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