Mp77-19 baseline psa levels in men aged 40-60 are influenced by race, body mass index (bmi) and waist-circumference: a cross-sectional population-based study using the national health and nutrition examination survey (nhanes, 2001-2010)

You have accessJournal of UrologyProstate Cancer: Detection and Screening VI1 Apr 2015MP77-19 BASELINE PSA LEVELS IN MEN AGED 40-60 ARE INFLUENCED BY RACE, BODY MASS INDEX (BMI) AND WAIST-CIRCUMFERENCE: A CROSS-SECTIONAL POPULATION-BASED STUDY USING THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES, 2001-2010) Mark A. Preston, Julie L. Batista, Samuel F. Peisch, Sarah Markt, Taylor Medwig, Kathryn M. Wilson, Quoc-Dien Trinh, Adam S. Kibel, Meir Stampfer, and Lorelei A. Mucci Mark A. PrestonMark A. Preston More articles by this author , Julie L. BatistaJulie L. Batista More articles by this author , Samuel F. PeischSamuel F. Peisch More articles by this author , Sarah MarktSarah Markt More articles by this author , Taylor MedwigTaylor Medwig More articles by this author , Kathryn M. WilsonKathryn M. Wilson More articles by this author , Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author , Adam S. KibelAdam S. Kibel More articles by this author , Meir StampferMeir Stampfer More articles by this author , and Lorelei A. MucciLorelei A. Mucci More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.559AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is increasing evidence that a baseline PSA during mid-life can predict future development of lethal prostate cancer. We determined baseline PSA levels for US men aged 40 to 60 years in a nationally representative cohort and studied the influence of race, BMI, and waist circumference on median PSA levels among men without diagnosed prostate cancer. METHODS We leveraged data from the National Health and Nutrition Examination Survey (NHANES), a set of studies that gathers lifestyle and nutrition information, and includes in person clinical assessments and biomarker measures. The study was nested among men with PSA measured between 2001-2010. Those with current infection or prostate inflammation, rectal exam in the past week, prostate biopsy or cystoscopy in the past month, or with a history of prostate cancer were excluded from PSA testing. We constructed a multivariable linear regression model to determine associations between age, body mass index (BMI), waist circumference, race, and log-transformed total PSA. RESULTS There were 3,972 men aged 40 to 60 with PSA measured, of whom 49% were white, 20% black and 19% Mexican-American. Median total PSA levels by race, BMI and waist circumference are outlined in the table. In multivariable models, older age was positively associated with PSA levels. Moreover, PSA levels were higher among men of African-American and Mexican-American ancestry, compared to non-Hispanic white ancestry. In contrast, men with higher BMI or greater waist circumference had lower total PSA levels, adjusting for age and race. CONCLUSIONS This study is among the first to report racial differences in PSA levels among men in midlife, and showing higher levels among African-American, and Mexican-American men. Conversely, BMI and waist circumference were inversely associated with PSA levels, and these associations were independent of race or age. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1001 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mark A. Preston More articles by this author Julie L. Batista More articles by this author Samuel F. Peisch More articles by this author Sarah Markt More articles by this author Taylor Medwig More articles by this author Kathryn M. Wilson More articles by this author Quoc-Dien Trinh More articles by this author Adam S. Kibel More articles by this author Meir Stampfer More articles by this author Lorelei A. Mucci More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...