Mp58-02 pre-chemotherapy neutrophil-to-lymphocyte ratio correlates with cancer-specific and overall mortality in patients with metastatic urothelial carcinoma

You have accessJournal of UrologyBladder Cancer: Invasive II1 Apr 2015MP58-02 PRE-CHEMOTHERAPY NEUTROPHIL-TO-LYMPHOCYTE RATIO CORRELATES WITH CANCER-SPECIFIC AND OVERALL MORTALITY IN PATIENTS WITH METASTATIC UROTHELIAL CARCINOMA Satoru Taguchi, Tohru Nakagawa, Akihiko Matsumoto, Yasushi Nagase, Taketo Kawai, Yoshinori Tanaka, Kanae Yoshida, Sachi Yamamoto, Yutaka Enomoto, Yorito Nose, Toshikazu Sato, Akira Ishikawa, Yukari Uemura, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, and Yukio Homma Satoru TaguchiSatoru Taguchi More articles by this author , Tohru NakagawaTohru Nakagawa More articles by this author , Akihiko MatsumotoAkihiko Matsumoto More articles by this author , Yasushi NagaseYasushi Nagase More articles by this author , Taketo KawaiTaketo Kawai More articles by this author , Yoshinori TanakaYoshinori Tanaka More articles by this author , Kanae YoshidaKanae Yoshida More articles by this author , Sachi YamamotoSachi Yamamoto More articles by this author , Yutaka EnomotoYutaka Enomoto More articles by this author , Yorito NoseYorito Nose More articles by this author , Toshikazu SatoToshikazu Sato More articles by this author , Akira IshikawaAkira Ishikawa More articles by this author , Yukari UemuraYukari Uemura More articles by this author , Tetsuya FujimuraTetsuya Fujimura More articles by this author , Hiroshi FukuharaHiroshi Fukuhara More articles by this author , Haruki KumeHaruki Kume More articles by this author , and Yukio HommaYukio Homma More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2141AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Neutrophil-to-lymphocyte ratio (NLR) has recently been demonstrated to be a prognostic factor in many malignancies but not explored in metastatic urothelial carcinoma (UC). METHODS We reviewed 200 metastatic UC patients who received salvage chemotherapy at our five affiliate institutions between 2003 and 2011. The associations of pretreatment clinicopathologic factors, including NLR, with cancer-specific survival (CSS) and overall survival (OS) from the start of chemotherapy were assessed. Cox proportional hazards model was used for multivariate analysis. RESULTS Of 185 cases after excluding 15 with missing data, 157 were dead during the follow-up with a median survival of 13.0 months. Multivariate analysis demonstrated that pretreatment NLR ≥3, ECOG performance status ≥2, and liver metastasis were independent poor prognostic factors, both for CSS and OS. A prognostic model predicting OS was constructed based on the number of these three variables (0, 1, and ≥2). The classified patients showed significantly different OS (each p <0.0001, log-rank test), with the Harrell's concordance index as high as 0.81. CONCLUSIONS Pre-chemotherapy NLR elevation was an independent poor prognostic factor in patients with metastatic UC. Our newly-constructed prognostic model including pre-chemotherapy NLR proved to be an excellent discriminator of OS. This information may be useful for patient counseling, clinical decision making, and clinical trial design. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e721-e722 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Satoru Taguchi More articles by this author Tohru Nakagawa More articles by this author Akihiko Matsumoto More articles by this author Yasushi Nagase More articles by this author Taketo Kawai More articles by this author Yoshinori Tanaka More articles by this author Kanae Yoshida More articles by this author Sachi Yamamoto More articles by this author Yutaka Enomoto More articles by this author Yorito Nose More articles by this author Toshikazu Sato More articles by this author Akira Ishikawa More articles by this author Yukari Uemura More articles by this author Tetsuya Fujimura More articles by this author Hiroshi Fukuhara More articles by this author Haruki Kume More articles by this author Yukio Homma More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...