WHAT PREDICTS LONG TERM SEXUAL DYSFUNCTION FOR MEN ON ACTIVE SURVEILLANCE FOR PROSTATE CANCER?

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation (II)1 Apr 20131396 WHAT PREDICTS LONG TERM SEXUAL DYSFUNCTION FOR MEN ON ACTIVE SURVEILLANCE FOR PROSTATE CANCER? Jeffrey Albaugh, Brian Helfand, David Victorson, Kristian Novakovic, Charles Brendler, Jaclyn Pruitt, Sarah Rabbitt, and Michael McGuire Jeffrey AlbaughJeffrey Albaugh Evanston, IL More articles by this author , Brian HelfandBrian Helfand Evanston, IL More articles by this author , David VictorsonDavid Victorson Chicago, IL More articles by this author , Kristian NovakovicKristian Novakovic Evanston, IL More articles by this author , Charles BrendlerCharles Brendler Evanston, IL More articles by this author , Jaclyn PruittJaclyn Pruitt Evanston, IL More articles by this author , Sarah RabbittSarah Rabbitt Evanston, IL More articles by this author , and Michael McGuireMichael McGuire Evanston, IL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2750AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is current debate regarding the possible relationship between repeat prostate biopsies and sexual dysfunction. Factors that have been associated with erectile dysfunction have included the number of cores obtained, serial biopsies, type of anesthetic and psychological factors. We sought to define the relationship(s) between serial biopsies and clinical characteristics, including anxiety and sexual dysfunction, in a cohort of men with prostate cancer (PC) undergoing active surveillance (AS). METHODS As a part of an IRB-approved AS protocol, several patient-reported outcomes measures are administered at enrollment and regular 6 month intervals to assess how AS influences QOL, psychosocial and urological health outcomes. Using multiple linear regression, we examined whether repeat biopsies, total number of cores taken, anxiety (measured by Memorial Anxiety Score for PC) and age, jointly affect sexual function (measured by EPIC-26 Sexual Dysfunction subscale) over the first 24 months of enrolling in AS. Independent variables were centered and the dependent variable was the level of sexual dysfunction. RESULTS The mean age was 66.9±6.7 with a mean EPIC-26 sexual dysfunction subscale score of 34.4 (SD = 30.1) and increasing to a score of 47.5 (SD = 30.8) at 24 months (Figure 1), out of a possible 100 (with higher scores indicating worse sexual dysfunction). Each time point (enrollment, 6, 12, 18, 24 months) produced significant models (p<0.01) with adjusted r2 values ranging from .22 to .27, or roughly 22-27% of the variability in sexual dysfunction scores could be attributed to the specified model. Upon examination of unique variables, age was the only significant independent predictor at every time point (standardized regression coefficients between .48 to .53, p<0.01), while anxiety, number of biopsies and total cores taken did not predict sexual dysfunction. CONCLUSIONS Serial biopsy did not independently predict worse sexual function in men on AS. Overall, the change in sexual function over time appeared to be most related to increasing age. Further studies are needed to determine whether additional factors associated with aging, such as comorbid conditions and medications, also influence sexual dysfunction. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e571 Peer Review Report Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffrey Albaugh Evanston, IL More articles by this author Brian Helfand Evanston, IL More articles by this author David Victorson Chicago, IL More articles by this author Kristian Novakovic Evanston, IL More articles by this author Charles Brendler Evanston, IL More articles by this author Jaclyn Pruitt Evanston, IL More articles by this author Sarah Rabbitt Evanston, IL More articles by this author Michael McGuire Evanston, IL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...