MP10-15 DYNAMIC SENTINEL LYMPH NODE BIOPSY IN PENILE CANCER: A SINGLE CENTRE EXPERIENCE

You have accessJournal of UrologyPenis/Testis: Benign & Malignant Disease II1 Apr 2014MP10-15 DYNAMIC SENTINEL LYMPH NODE BIOPSY IN PENILE CANCER: A SINGLE CENTRE EXPERIENCE Jonathan Patrick Noël, Raj Prasenjit Pal, Jonathan Charles Goddard, Tim Robin Terry, Yvonne Rees, John Paul Dormer, and Duncan John Summerton Jonathan Patrick NoëlJonathan Patrick Noël More articles by this author , Raj Prasenjit PalRaj Prasenjit Pal More articles by this author , Jonathan Charles GoddardJonathan Charles Goddard More articles by this author , Tim Robin TerryTim Robin Terry More articles by this author , Yvonne ReesYvonne Rees More articles by this author , John Paul DormerJohn Paul Dormer More articles by this author , and Duncan John SummertonDuncan John Summerton More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.471AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Dynamic sentinel lymph node biopsy (DSNB) has become the recommended approach to assess lymph node status in men with clinically impalpable inguinal nodes and ≥G2T1 penile cancer. A limited number of centres publish results and require validation from other groups. We present intermediate term outcomes of our patients undergoing DSNB in a supra-regional tertiary referral penile cancer centre. METHODS All patients with ≥G2T1 penile squamous cell carcinoma and non-palpable nodes underwent uni/bilateral DSNB between July 2010 to September 2013. Patients were assessed by lymphoscintigraphy using (99m) technetium labelled nanocolloid, followed by inguinal ultrasound scan on the morning of surgery. At the time of anaesthetic induction, 1ml of patent blue dye was injected into the proximal penile shaft. Retrieval of sentinel nodes was facilitated by the use of pre-operative lymphoscintigraphic images and intra-operative detection of radiotracer and patent blue dye. The primary outcome measure was the incidence of node metastasis and our false negative rate of DSNB. Secondary end points evaluated were preoperative predictors of lymph node metastasis detection and complications following DSNB. RESULTS In total, 87 inguinal basins from 47 patients underwent DSNB. Post-operative outcomes were evaluated at a median follow up period of 15 months (range 1-33 months). Six patients (13%) demonstrated positive DSNB (one patient had bilateral metastasis). To date, no patients have been identified with having false negative findings after DSNB. Predictive factors for the detection of positive nodes were tumour grade (P=0.031) and lymphovascular invasion (P=0.004). Tumour stage and intra-operative radiotracer count did not predict nodes likely to harbour metastasis. Complications related to DSNB were seen in 1 patient (2%) who had groin pain and swelling that settled conservatively. CONCLUSIONS Our findings support previous data, suggesting that DSNB can identify lymph node metastasis in patients, without subjecting them to the complications of radical inguinal lympadenectomy. In particular, we demonstrated that primary tumour grade and lympovascular invasion are important predictors of DSNB histological outcome. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e119-e120 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Jonathan Patrick Noël More articles by this author Raj Prasenjit Pal More articles by this author Jonathan Charles Goddard More articles by this author Tim Robin Terry More articles by this author Yvonne Rees More articles by this author John Paul Dormer More articles by this author Duncan John Summerton More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...