MP14-07 WHAT ARE WE MISSING? THE PERSISTENCE OF VITALITY SYMPTOM BURDEN IN LONG-TERM PROSTATE CANCER SURVIVORS WITHOUT RECURRENT DISEASE

quality and frequency of erections, overall sexual function and a bother index. Most questions had a score from 1e5 (11⁄4very poor, 51⁄4very good). Each number was mapped to a 0e100 score and scores were averaged to create an overall sexual function score ranging from 0e100. Men with a positive biopsy were divided into low(Gleason 6) and high-grade (Gleason 7) disease. Logistic regression was used to test the link between sexual function and PC risk. Multinomial logistic regression was used to test the association between sexual function and risk of low-grade vs. no cancer and risk of high-grade vs. no cancer. RESULTS: 209 (47%) men had a positive biopsy; these men were less likely to be white (43% vs. 55%, p1⁄40.01), more recently accrued (2010 vs. 2009, p1⁄40.002), had higher PSA (6.0 vs. 5.4ng/ml, pu003c0.001) but lower mean sexual function score (47 vs. 54, pu003c0.001). There was no difference in age, BMI, pack years smoked, history of heart disease and/or diabetes. Sexual function was linked with a decreased risk of overall PC risk (OR 0.91 per 10-pt change in sexual function, p1⁄40.004) and high grade disease (OR 0.86, p1⁄40.001). There was no association between sexual function and low grade PC. CONCLUSIONS: Among men undergoing prostate biopsy, higher sexual function was associated with a decreased risk of overall and high-grade PC. Confirmatory studies are needed.