1744 IMPROVEMENTS IN LOWER URINARY TRACT SYMPTOM SEVERITY ARE ASSOCIATED WITH IMPROVEMENTS IN SLEEP DISTURBANCE OVER TIME

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20121744 IMPROVEMENTS IN LOWER URINARY TRACT SYMPTOM SEVERITY ARE ASSOCIATED WITH IMPROVEMENTS IN SLEEP DISTURBANCE OVER TIME Brian T. Helfand, Victoria Sharp, O. Dale Williams, Harris Foster, Michael Naslund, Jeanette Lee, and Kevin T. McVary Brian T. HelfandBrian T. Helfand Chicago, IL More articles by this author , Victoria SharpVictoria Sharp Iowa City, IA More articles by this author , O. Dale WilliamsO. Dale Williams Birmingham, AL More articles by this author , Harris FosterHarris Foster New Haven, CT More articles by this author , Michael NaslundMichael Naslund Baltimore, MD More articles by this author , Jeanette LeeJeanette Lee Little Rock, AR More articles by this author , and Kevin T. McVaryKevin T. McVary Chicago, IL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1705AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We recently documented an association between the bother and severity of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and the severity of sleep disturbance [J Urol.185(6): 2223]. However, few studies have examined whether alterations in the severity of urinary symptoms influence the degree of sleep problems over time. METHODS The severity of LUTS of men enrolled in a clinical trial of saw palmetto (Serenoa repens) were evaluated using the AUA-symptom index (AUASI) and QoL scores and the degree of sleep disturbance was determined by the Jenkins Sleep Scale (scale of increasing sleep disturbance from 0-20 points) at 0, 24, 48 and 72 months. Statistical analyses were performed to assess the relationship(s) between changes in LUTS and sleep disturbance over time. RESULTS The baseline characteristics of the 339 men (172 placebo arm and 167 saw palmetto arm) enrolled in the CAMUS trial with assessment of sleep disturbance and urinary symptoms were similar. There were no differences between improvements in the severity of sleep disturbance or urinary symptoms between the two experimental arms over time. Combined analyses of the entire cohort revealed a significant association between the total AUASI score and sleep disturbance severity over time (p<0.001). Multivariate analyses demonstrated that nocturia is an independent predictor of sleep quality (Figure). Interestingly, LUTS, other than nocturia, were the most significant predictor of improvements in sleep disturbance (Figure, p<0.001). Specific analyses adjusting for other baseline characteristics demonstrated that for every 3 point improvement in AUASI score there was a 0.73 point improvement in the Jenkins sleep scale over time. CONCLUSIONS Improvements in LUTS correlate with improvements in sleep quality over time in men with BPH. While nocturia is significantly associated with sleep disturbance, other changes in overall LUTS are better predictors of changes in sleep dysfunction over time. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e703-e704 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brian T. Helfand Chicago, IL More articles by this author Victoria Sharp Iowa City, IA More articles by this author O. Dale Williams Birmingham, AL More articles by this author Harris Foster New Haven, CT More articles by this author Michael Naslund Baltimore, MD More articles by this author Jeanette Lee Little Rock, AR More articles by this author Kevin T. McVary Chicago, IL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...