AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric cancer cells

Chiara Stella Di Stadio,Filomena Altieri,Giuseppina Miselli,Ausilia Elce,Valeria Severino,Angela Chambery,Vincenzo Quagliariello,Valentina Villano, Gianfranco de Dominicis,Emilia Rippa,Paolo Arcari

Biochimie（2016）

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摘要

AMP18 is a stomach-specific secreted protein expressed in normal gastric mucosa but absent in gastric cancer. AMP18 plays a major role in maintaining gastric mucosa integrity and is characterized by the presence of a BRICHOS domain consisting of about 100 amino acids, present also in several unrelated proteins, and probably endowed with a chaperon-like activity.

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关键词

Antrum mucosal protein,Gastric cancer,Brichos domain,Down-Regulated in Adenoma

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