High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013-2019.

Multidrug-resistant (MDR) has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of in a Peruvian hospital from 2013 to 2019. A total of 993 clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.