Phosphaannulation of Aryl‐ and Benzylphosphonic Acids with Unactivated Alkenes via Palladium‐Catalyzed CH Activation/Oxidative Cyclization Reaction
Advanced Synthesis and Catalysis(2015)
Abstract
An efficient phosphaannulation via palladium(II)‐catalyzed CH activation/oxidative cyclization by the 6‐endo mode is reported for the synthesis of 3‐substituted phosphaisocoumarins from the reaction of arylphosphonic acids with unactivated alkenes under aerobic conditions. Also, α,α‐disubstituted benzylphosphonic acids were phosphaannulated with unactivated alkenes, producing phosphaisochromanones having (Z)‐alkylidenyl groups via anti‐phosphoryloxypalladation by the 6‐exo mode.
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Key words
CH activation,palladium,phosphaannulation,phosphaisochromanones,phosphaisocoumarins
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