Accelerated Partial Breast Irradiation Using Sole Interstitial Multicatheter Brachytherapy Versus Whole Breast Irradiation for Early Breast Cancer: Five-Year Results of a Randomized Phase 3 Trial – Part I: Local Control and Survival Results

Standard local treatment for patients with early breast cancer is breast-conserving surgery (BCS) followed by adjuvant whole breast irradiation (WBI). We aimed to assess the effect of accelerated partial breast irradiation (APBI) on local control for patients with stage 0, I, and IIA breast cancer who underwent breast-conserving treatment compared with patients who received WBI with boost. In part I we report mature 5-year local control and survival results of a multicenter randomized noninferiority trial comparing APBI using sole multicatheter brachytherapy to standard WBI.